Placental insufficiency leads to developmental hypertension and mesenteric artery dysfunction in two generations of Sprague-Dawley rat offspring.

@article{Anderson2006PlacentalIL,
  title={Placental insufficiency leads to developmental hypertension and mesenteric artery dysfunction in two generations of Sprague-Dawley rat offspring.},
  author={Cindy Miller Anderson and F. L{\'o}pez L{\'o}pez and Ashley Zimmer and Joseph N. Benoit},
  journal={Biology of reproduction},
  year={2006},
  volume={74 3},
  pages={538-44}
}
It is generally accepted that preeclampsia results from reduction in perfusion to the uteroplacental unit leading to maternal hypertension and fetal growth restriction. Placental insufficiency creates an environment of fetal undernutriton, predisposing the fetus to the development of adult disease. In this study, we characterized the development and perpetuation of hypertension in two generations of male and female offspring subjected to an environment of fetal undernutrition via reduced… CONTINUE READING
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