Placental imbalance of vasoactive factors does not affect pregnancy outcome in patients treated with Cyclosporine A after transplantation.

@article{Paolo2002PlacentalIO,
  title={Placental imbalance of vasoactive factors does not affect pregnancy outcome in patients treated with Cyclosporine A after transplantation.},
  author={Salvatore di Paolo and Raffaella Monno and Giovanni Stallone and Giuseppe Grandaliano and Antonio Schena and Pantaleo Greco and Paolo Volpe and Leonardo Resta and Luigi Selvaggi and Francesco Paolo Schena and Loreto Gesualdo},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2002},
  volume={39 4},
  pages={
          776-83
        }
}
Endothelin-1 (ET-1) and nitric oxide (NO) have been suggested to have a focal role in the regulation of placental and fetal growth. Cyclosporine A (CsA) has been shown to strongly modulate ET-1 and NO synthesis and thus has the potential to affect fetal growth and maternal state. Eleven CsA-treated female kidney transplant recipients were recruited. Fourteen healthy pregnant women served as controls. Placental expression of ET-1 and tissue factor (TF) was evaluated by in situ hybridization, and… CONTINUE READING
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