Placental growth factor induces FosB and c‐Fos gene expression via Flt‐1 receptors

@article{Holmes2004PlacentalGF,
  title={Placental growth factor induces FosB and c‐Fos gene expression via Flt‐1 receptors},
  author={David Ian Roderick Holmes and Ian C. Zachary},
  journal={FEBS Letters},
  year={2004},
  volume={557}
}
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TLDR
Vascular endothelial growth factor expression levels were found to be significantly lower in the frontal cortex of Pl GF−/− compared with those in PlGF+/+ animals during the first 5 days of hypoxia, which in combination with the lack of PlGF may have contributed to the delayed angiogenic response and the prothrombotic phenotype observed in the PlGF −/−animals.
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RGS13 acts as a nuclear repressor of CREB.
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References

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TLDR
Flt 1 is able to mediate an array of biological signals when appropriately stimulated and that the pattern of responses of PlGF-stimulation of Flt 1 is distinct from thepattern of responses to VEGF- Stimulation of KDR.
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TLDR
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TLDR
It is reported that embryonic angiogenesis in mice was not affected by deficiency of PlGF, andTransplantation of wild-type bone marrow rescued the impairedAngiogenesis and collateral growth in Pgf−/− mice, indicating that PlGF might have contributed to vessel growth in the adult by mobilizing bone-marrow–derived cells.
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TLDR
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