Placental glutathione-S-transferase-pi mRNA is abundantly expressed in human skin.

@article{Konohana1990PlacentalGM,
  title={Placental glutathione-S-transferase-pi mRNA is abundantly expressed in human skin.},
  author={A. Konohana and I. Konohana and Wilfried Schroeder and Walter R O'Brien and Masayuki Amagai and Jerry Greer and Noriaki Shimizu and W R Gammon and Michael J. Siciliano and Madeleine Duvic},
  journal={The Journal of investigative dermatology},
  year={1990},
  volume={95 2},
  pages={119-26}
}
Four overlapping cDNA clones were isolated from a lambda gt11 human placenta cDNA library using purified human IgG antibody, from a patient with bullous pemphigoid. The sequence was homologous to human placenta glutathione-S-transferase-pi (GST-pi). Using the placenta clone, epidermal cDNA clones were isolated from a human keratinocyte library. Expression of GST-pi mRNA in human skin, cultured keratinocytes and fibroblasts, and disorders of squamous hyperplasia was demonstrated by Northern… CONTINUE READING