Placental failure in mice lacking the homeobox gene Dlx3.

@article{Morasso1999PlacentalFI,
  title={Placental failure in mice lacking the homeobox gene Dlx3.},
  author={Maria I Morasso and A. S. Grinberg and Graham Robinson and T. D. Sargent and Kathleen A. Mahon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 1},
  pages={
          162-7
        }
}
Dlx3 is a homeodomain transcription factor and a member of the vertebrate Distal-less family. Targeted deletion of the mouse Dlx3 gene results in embryonic death between day 9.5 and day 10 because of placental defects that alter the development of the labyrinthine layer. In situ hybridization reveals that the Dlx3 gene is initially expressed in ectoplacental cone cells and chorionic plate, and later in the labyrinthine trophoblast of the chorioallantoic placenta, where major defects are… CONTINUE READING

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