Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor II.

@article{Giri2006PlacentalDS,
  title={Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor II.},
  author={Tusar K Giri and Douglas M. Tollefsen},
  journal={Blood},
  year={2006},
  volume={107 7},
  pages={2753-8}
}
Pregnancy is associated with hemostatic challenges that may lead to thrombosis. Heparin cofactor II (HCII) is a glycosaminoglycan-dependent thrombin inhibitor present in both maternal and fetal plasma. HCII activity increases during pregnancy, and HCII levels are significantly decreased in women with severe pre-eclampsia. Dermatan sulfate (DS) specifically activates HCII and is abundant in the placenta, but the locations of DS and HCII in the placenta have not been determined. We present… CONTINUE READING