Placental corticotropin-releasing hormone: function and regulation.

  title={Placental corticotropin-releasing hormone: function and regulation.},
  author={Joseph A. Majzoub and Katia P. Karalis},
  journal={American journal of obstetrics and gynecology},
  volume={180 1 Pt 3},
Corticotropin-releasing hormone is a neuropeptide placentally expressed among mammals only in primates. Its expression increases as much as 100 times during the last 6 to 8 weeks of pregnancy and is paradoxically stimulated by glucocorticoids. Increasing evidence suggests that placental corticotropin-releasing hormone may have evolved in primates to stimulate fetal adrenocorticotropin release and adrenal steroidogenesis, thus satisfying the high demand for synthesis of dehydroepiandrosterone… CONTINUE READING
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