Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients.

@article{Kurtzberg1996PlacentalBA,
  title={Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients.},
  author={Joan Kurtzberg and Mark M Laughlin and Michael L. Graham and Chad Smith and J F Olson and Edward Charles Halperin and G H Ciocci and Caroline Carrier and Claire E. Stevens and Pablo Rubinstein},
  journal={The New England journal of medicine},
  year={1996},
  volume={335 3},
  pages={157-66}
}
BACKGROUND Transplantation of bone marrow from unrelated donors is limited by a lack of HLA-matched donors and the risk of graft-versus-host disease (GVHD). Placental blood from sibling donors can reconstitute hematopoiesis. We report preliminary results of transplantation using partially HLA-mismatched placental blood from unrelated donors. METHODS Twenty-five consecutive patients, primarily children, with a variety of malignant and non-malignant conditions received placental blood from… CONTINUE READING

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