Placental aminopeptidase A as a possible barrier of angiotensin II between mother and fetus.

@article{Hariyama2000PlacentalAA,
  title={Placental aminopeptidase A as a possible barrier of angiotensin II between mother and fetus.},
  author={Yumi Hariyama and Atsuo Itakura and Miyako Okamura and Mitsuaki Ito and Yukihito Murata and Tetsuo Nagasaka and Hitoshi Nakazato and Shigehiko Mizutani},
  journal={Placenta},
  year={2000},
  volume={21 7},
  pages={621-7}
}
Aminopeptidase A (AP-A EC 3.4.11.7), which is a membrane-bound zinc metalloprotease, is present in the placenta. AP-A selectively hydrolyzes N-terminal glutamyl and aspartyl residues and cleaves angiotensin II to form angiotensin III. To determine the role of placental aminopeptidase A under physiological and pathological conditions, we evaluated its immunolocalization and enzymatic activities in the placenta. AP-A was localized in the basal zone of the syncytiotrophoblast, in the membranes of… CONTINUE READING

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