Placental Transfer of Conjugated Bisphenol A and Subsequent Reactivation in the Rat Fetus

@inproceedings{Nishikawa2010PlacentalTO,
  title={Placental Transfer of Conjugated Bisphenol A and Subsequent Reactivation in the Rat Fetus},
  author={Miyu Nishikawa and Hidetomo Iwano and Risa Yanagisawa and Nanako Koike and Hiroki Inoue and Hiroshi Yokota},
  booktitle={Environmental health perspectives},
  year={2010}
}
BACKGROUND Bisphenol A (BPA), a well-known endocrine disruptor, is highly glucuronidated in the liver, and the resultant BPA-glucuronide (BPA-GA) is excreted primarily into bile. However, in rodents, prenatal exposure to low doses of BPA can adversely affect the fetus, despite the efficient drug-metabolizing systems of the dams. The transport mechanisms of BPA from mother to fetus are unknown. OBJECTIVES To test our hypothesis that BPA-GA-an inactive metabolite-is passed through the placenta… CONTINUE READING

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