Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension.

  title={Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension.},
  author={Frank T Spradley and Adelene Y Tan and Woo S Joo and G. P. Daniels and Paul Kussie and Siddharth Karumanchi and Joey P. Granger},
  volume={67 4},
Preeclampsia is a pregnancy-specific disorder of new-onset hypertension. Unfortunately, the most effective treatment is early delivery of the fetus and placenta. Placental ischemia appears central to the pathogenesis of preeclampsia because placental ischemia/hypoxia induced in animals by reduced uterine perfusion pressure (RUPP) or in humans stimulates release of hypertensive placental factors into the maternal circulation. The anti-angiogenic factor soluble fms-like tyrosine kinase-1 (sFlt-1… CONTINUE READING
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and type 2 diabetes mellitus after a hypertensive disorder of pregnancy or gestational diabetes mellitus

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