Placental Expression of Angiopoietin-1, Angiopoietin-2 and Tie-2 during Placental Development in an Ovine Model of Placental Insufficiency-Fetal Growth Restriction

@article{Hagen2005PlacentalEO,
  title={Placental Expression of Angiopoietin-1, Angiopoietin-2 and Tie-2 during Placental Development in an Ovine Model of Placental Insufficiency-Fetal Growth Restriction},
  author={Amy S Erickson Hagen and Ryan J Orbus and Randall B. Wilkening and Timothy R H Regnault and Russell V Anthony},
  journal={Pediatric Research},
  year={2005},
  volume={58},
  pages={1228-1232}
}
Fetal growth restriction (FGR) is associated with increased perinatal morbidity and mortality, and often results from functional placental insufficiency. Placentation requires extensive vasculogenesis and subsequent angiogenesis, in both maternal and fetal tissues. Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are angiogenic growth factors expressed in the placenta, and compete for binding to a common receptor, Tunica interna endothelial cell kinase-2 (Tie-2). Our objective was to examine… CONTINUE READING

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