Placental ATPase expression is a link between multiple causes of spontaneous abortion in mice.

@article{Jaiswal2011PlacentalAE,
  title={Placental ATPase expression is a link between multiple causes of spontaneous abortion in mice.},
  author={Mukesh Kumar Jaiswal and Alice Gilman-Sachs and G{\'e}rard Chaouat and Kenneth D. Beaman},
  journal={Biology of reproduction},
  year={2011},
  volume={85 3},
  pages={626-34}
}
The a2 isoform of vacuolar ATPase (ATP6V0A2 referred to as a2V) plays a pivotal role in successful pregnancy and provides a microenvironment to maintain the delicate immunological balance at the feto-maternal interaction. We studied the expression of a2V mRNA in embryos and placenta of abortion-prone (female CBA × male DBA) murine matings or LPS (lipopolysaccharide)-treated mice. The expression of a2V was significantly higher in the placentas of nonabortion-prone (female BALB/c × male BALB/c… CONTINUE READING

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