Placental 11 beta-hydroxysteroid dehydrogenase activity in normotensive and pre-eclamptic pregnancies.

@article{McCalla1998Placental1B,
  title={Placental 11 beta-hydroxysteroid dehydrogenase activity in normotensive and pre-eclamptic pregnancies.},
  author={Cyrus O McCalla and Vijaya L Nacharaju and Ozgul Muneyyirci-Delale and Stephen Glasgow and Joseph G. Feldman},
  journal={Steroids},
  year={1998},
  volume={63 10},
  pages={511-5}
}
Apparent mineralocorticoid excess and licorice induced hypertension, both hypertensive disorders, have been attributed to a defect in the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), which interconverts cortisol to cortisone. Therefore, we undertook this study to determine the role of human placental 11 beta-HSD activity in preeclampsia, which is a hypertensive disorder in pregnancy. 11 beta-HSD activities were determined in placentas of 17 normotensive and 11 preeclamptic… CONTINUE READING

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