Placental 11-Hydroxysteroid Dehydrogenase in Dahl and Spontaneously Hypertensive Rats

@inproceedings{Sedmera2003Placental1D,
  title={Placental 11-Hydroxysteroid Dehydrogenase in Dahl and Spontaneously Hypertensive Rats},
  author={David Sedmera and Jaroslav Kunes̆},
  year={2003}
}
Studies in normotensive rats showed that excessive fetal exposure to maternal glucocorticoids retards growth and programs hypertension in later life. This excessive exposure is proposed to occur due to a reduction of the placental barrier to maternal glucocorticoids that is provided by 11 -hydroxysteroid dehydrogenase (11 HSD). To assess the possible alterations of glucocorticoid placental barrier in two genetic models of hypertension — spontaneously hypertensive (SHR) and Dahl salt-sensitive… CONTINUE READING
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