Placental 11-Hydroxysteroid Dehydrogenase in Dahl and Spontaneously Hypertensive Rats

  title={Placental 11-Hydroxysteroid Dehydrogenase in Dahl and Spontaneously Hypertensive Rats},
  author={David Sedmera and Jaroslav Kunes̆},
Studies in normotensive rats showed that excessive fetal exposure to maternal glucocorticoids retards growth and programs hypertension in later life. This excessive exposure is proposed to occur due to a reduction of the placental barrier to maternal glucocorticoids that is provided by 11 -hydroxysteroid dehydrogenase (11 HSD). To assess the possible alterations of glucocorticoid placental barrier in two genetic models of hypertension — spontaneously hypertensive (SHR) and Dahl salt-sensitive… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 30 references

Struijker-Boudier HAJ: High dietary potassium chloride intake augments rat renal mineralocorticoid receptor selectivity via 11 -hydroxysteroid dehydrogenase

  • JJR Hermans, MAJ Fisher, PM Schiffers
  • Biochim Biophys Acta 1999;1472:537–549
  • 1999
Highly Influential
2 Excerpts

Miks̆ı́k I: 11 -Hydroxysteroid dehydrogenase in developing rat intestine

  • J Pácha
  • J Endocrinol
  • 1996
Highly Influential
2 Excerpts

Pácha J: 11 -hydroxysteroid dehydrogenase activity in spontaneously hypertensive and Dahl rats

  • I Pohlová, I Miks̆ı́k, J Kunes
  • Am J Hypertens
  • 2000
1 Excerpt

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