Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene

@article{Novakovic2009PlacentaspecificMO,
  title={Placenta-specific Methylation of the Vitamin D 24-Hydroxylase
 Gene},
  author={Boris Novakovic and Mandy Sibson and Hong Kiat Ng and Ursula Manuelpillai and Vardhman Rakyan and Thomas Down and Stephan Beck and Thierry Fournier and Danielle Evain-Brion and Evdokia Dimitriadis and Jeffrey M Craig and Ruth Morley and Richard Saffery},
  journal={The Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={14838 - 14848}
}
Plasma concentrations of biologically active vitamin D (1,25-(OH)(2)D) are tightly controlled via feedback regulation of renal 1alpha-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes. In pregnancy, this regulation is uncoupled, and 1,25-(OH)(2)D levels are significantly elevated, suggesting a role in pregnancy progression. Epigenetic regulation of CYP27B1 and CYP24A1 has previously been described in cell and animal models, and despite emerging evidence for a… CONTINUE READING
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