Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene

  title={Placenta-specific Methylation of the Vitamin D 24-Hydroxylase
  author={Boris Novakovic and Mandy Sibson and Hong Kiat Ng and Ursula Manuelpillai and Vardhman Rakyan and Thomas Down and Stephan Beck and Thierry Fournier and Danielle Evain-Brion and Evdokia Dimitriadis and Jeffrey M Craig and Ruth Morley and Richard Saffery},
  journal={The Journal of Biological Chemistry},
  pages={14838 - 14848}
Plasma concentrations of biologically active vitamin D (1,25-(OH)(2)D) are tightly controlled via feedback regulation of renal 1alpha-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes. In pregnancy, this regulation is uncoupled, and 1,25-(OH)(2)D levels are significantly elevated, suggesting a role in pregnancy progression. Epigenetic regulation of CYP27B1 and CYP24A1 has previously been described in cell and animal models, and despite emerging evidence for a… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS