Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential.

@article{Cianfarani2006PlacentaGF,
  title={Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential.},
  author={Francesca Cianfarani and Giovanna Zambruno and Laura Brogelli and Francesco Sera and Pedro Miguel Lacal and Maurizio Pesce and Maurizio Colognesi Capogrossi and Cristina M Failla and Monica Napolitano and Teresa Odorisio},
  journal={The American journal of pathology},
  year={2006},
  volume={169 4},
  pages={1167-82}
}
Reduced microcirculation and diminished expression of growth factors contribute to wound healing impairment in diabetes. Placenta growth factor (PlGF), an angiogenic mediator promoting pathophysiological neovascularization, is expressed during cutaneous wound healing and improves wound closure by enhancing angiogenesis. By using streptozotocin-induced diabetic mice, we here demonstrate that PlGF induction is strongly reduced in diabetic wounds. Diabetic transgenic mice overexpressing PlGF in… CONTINUE READING
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