Placenta cryosections for study of the adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A in flow conditions.

@article{Avril2004PlacentaCF,
  title={Placenta cryosections for study of the adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A in flow conditions.},
  author={Marion Avril and Boubacar Traore and Fabio T. M. Costa and Catherine L{\'e}polard and J{\"u}rg Gysin},
  journal={Microbes and infection},
  year={2004},
  volume={6 3},
  pages={249-55}
}
The adhesion of Plasmodium falciparum-infected erythrocytes (IEs) to chondroitin-4-sulfate (CSA) via the PfEMP1-CSA parasite ligand domain is correlated with placental malaria in primigravidae. The recent identification of parasite genes encoding CSA adhesion molecules and the development of pan-reactive monoclonal antibodies against the Pf(CSA) ligand have opened up new avenues for the development of anti-IE sequestration therapies for the prevention of placental malaria. A model closely… CONTINUE READING

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