Placebo use in vaccine trials: Recommendations of a WHO expert panel

Abstract

Vaccines are among the most cost-effective interventions against infectious diseases. Many candidate vaccines targeting neglected diseases in low- and middle-income countries are now progressing to large-scale clinical testing. However, controversy surrounds the appropriate design of vaccine trials and, in particular, the use of unvaccinated controls (with… (More)
DOI: 10.1016/j.vaccine.2014.04.022

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