Placebo response in neuropathic pain trials

  title={Placebo response in neuropathic pain trials},
  author={Steve N. Quessy and Michael C. Rowbotham},
Variability in response to ‘‘placebo” complicates the design and interpretation of clinical trials. Clinical trials of antidepressants for major depression have been plagued by high placebo responses across clinical trials with the same drug and substantially similar designs. In some cases, placebo response rates have been as high as 50–70% [5,29]. As with outcome measures in depression, pain intensity and pain relief are highly subjective constructs and clinical trials of analgesics are also… CONTINUE READING

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