Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 1: ethical and scientific issues.

@article{Temple2000PlacebocontrolledTA,
  title={Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 1: ethical and scientific issues.},
  author={Robert J. Temple and Susan S. Ellenberg},
  journal={Annals of internal medicine},
  year={2000},
  volume={133 6},
  pages={455-63}
}
Placebo-controlled trials are used extensively in the development of new pharmaceuticals. They are sometimes challenged as unethical in settings in which patients could be treated with an existing therapy (1-7). The issues of when placebo controls are ethically acceptable and when they are scientifically necessary are important and worthy of discussion. The Ethics of Placebo Controls The Declaration of Helsinki The Declaration of Helsinki (8) is an international document that describes ethical… CONTINUE READING
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Factors influencing clinical evaluation of drugs Medicine and Public Issues Placebo-Controlled Trials versus Active Control Trials: Part 1 462

  • W Modell, RW Houde
  • Annals of Internal Medicine Volume
  • 2000

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