Placebo-controlled trial of midazolam sedation in mechanically ventilated newborn babies.

@article{JacqzAigrain1994PlacebocontrolledTO,
  title={Placebo-controlled trial of midazolam sedation in mechanically ventilated newborn babies.},
  author={Evelyne Jacqz-Aigrain and Patrick Daoud and Pascale Burtin and Laurence Desplanques and Frangois Beaufils},
  journal={Lancet},
  year={1994},
  volume={344 8923},
  pages={646-50}
}
Although midazolam is used for sedation of mechanically ventilated newborn babies, this treatment has not been evaluated in a randomised trial. We have done a prospective placebo-controlled study of the effects of midazolam on haemodynamic variables and sedation as judged by a five-item behaviour score. 46 newborn babies on mechanical ventilation for respiratory distress syndrome were randomly assigned to receive midazolam (n = 24) or placebo (n = 22) as a continuous infusion. Doses of… CONTINUE READING

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