Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia.

@article{Kremer2004PlacebocontrolledTO,
  title={Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia.},
  author={Ilana Kremer and Agnes Vass and Ielena Gorelik and Gali Bar and Monica Blanaru and D. C. Javitt and Uriel Heresco-Levy},
  journal={Biological psychiatry},
  year={2004},
  volume={56 6},
  pages={441-6}
}
BACKGROUND Lamotrigine, a novel anticonvulsant drug having modulatory effects on glutamatergic neurotransmission, improves mood and cognition parameters in bipolar disorder. Recent studies suggest that when added to clozapine, lamotrigine treatment may result in significant positive symptoms reductions in schizophrenia. Similar effects were not observed in an open trial in which lamotrigine was used as adjuvant to nonclozapine antipsychotics. METHODS Thirty-eight treatment-resistant… CONTINUE READING

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