Placebo-controlled trial of cytisine for smoking cessation.

  title={Placebo-controlled trial of cytisine for smoking cessation.},
  author={Robert West and Witold A. Zatoński and Magdalena Cedzyńska and Dorota Lewandowska and Joanna Pazik and Paul Aveyard and John Stapleton},
  journal={The New England journal of medicine},
  volume={365 13},
BACKGROUND Cytisine, a partial agonist that binds with high affinity to the α(4)β(2) nicotinic acetylcholine receptor, is a low-cost treatment that may be effective in aiding smoking cessation. This study assessed the efficacy and safety of cytisine as compared with placebo. METHODS We conducted a single-center, randomized, double-blind, placebo-controlled trial. Participants were randomly assigned to receive cytisine or matching placebo for 25 days; participants in both groups received a… CONTINUE READING

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