Placebo-controlled trial of atenolol in treatment of pregnancy-associated hypertension.

@article{Rubin1983PlacebocontrolledTO,
  title={Placebo-controlled trial of atenolol in treatment of pregnancy-associated hypertension.},
  author={Peter C Rubin and L Butters and David M Clark and Branden Reynolds and David J. Sumner and D J Steedman and Richard Andrew Low and John L. Reid},
  journal={Lancet},
  year={1983},
  volume={1 8322},
  pages={431-4}
}
Atenolol was compared with placebo in a randomised and double-blind prospective study of 120 women with mild to moderate pregnancy-associated hypertension who were also initially managed conventionally by bed rest. Atenolol given once daily significantly reduced blood-pressure, prevented proteinuria, and reduced the number of hospital admissions. Loss of blood-pressure control leading to withdrawal from the study was commoner among the placebo group, whose babies had a high morbidity… CONTINUE READING
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