• Corpus ID: 51962225

Placebo controlled study on Comparison of effects of Nigella Sativa and Nicotinic Acid along with Low Fat Diet and Physical Exercise on LDL-Cholesterol and HDL-Cholesterol

  title={Placebo controlled study on Comparison of effects of Nigella Sativa and Nicotinic Acid along with Low Fat Diet and Physical Exercise on LDL-Cholesterol and HDL-Cholesterol},
  author={Hafiz Moeen-ud-Din and Shah Murad and Ajaz Fatima},
To get good compliance of therapeutic goal of hypolipidemic agents by cardiologist and patient, some herbal drugs have had been used by some expert cardiologists. Among those herbal medicines Kalonji is most important drug used as hypolipidemic agent. In this research work hypolipidemic effects of kalonji are compared with hypolipidemic effects of Niacin. It was single blind placebo-controlled comparative study, conducted at Jinnah Hospital, Lahore from September 2013 to December 2013. Ninety… 
Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials
This meta‐analysis demonstrated the beneficial effects of N. sativa on fasting glucose, HbA1c, triglycerides, total‐, VLDL‐, LDL‐cholesterol levels.
Effect of low caloric diet supplemented by fennel (Foeniculum vulgare) seeds or black cumin (Nigella sativa) seeds and its mixture on obese adult female patients
The present work was carried out to study the effect of low caloric diet supplemented with fennel seeds or black cumin seeds and their mixture on obese adult females. The control group (G1) used low
Cardiovascular Effects of Nigella Sativa L. and its Constituents
This review indicated that Nigella sativa and thymoquinone exhibited beneficial cardiovascular effects on cardiotoxicity, hypertension, hyperlipidemia, and atherosclerosis, probably due to the antioxidant and antiinflammatory properties of Nigella sitiva.
Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone
Some effects of N. sativa, such as its hypoglycemic, hypolipidemic and bronchodilatory effects, have been sufficiently studied and are sufficiently understood to allow for the next phase of clinical trials or drug developments.


Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus.
Despite improvement in lipid and lipoprotein concentrations, nicotinic acid must be used with caution in patients with non-insulin-dependent diabetes mellitus with dyslipidemia, because of worsening hyperglycemia and the development of hyperuricemia.
Comparative effects of lovastatin and niacin in primary hypercholesterolemia. A prospective trial.
Lovastatin was better tolerated than niacin and both exerted favorable dose-dependent changes on the concentrations of plasma lipids and lipoproteins in patients with primary hypercholesterolemia.
High prevalence of low HDL-cholesterol in a pan-European survey of 8545 dyslipidaemic patients
Low HDL-cholesterol and hypertriglyceridaemia are, therefore, common among European patients treated for dyslipidaemia and physicians need to focus more of their attention on this major risk factor and to consider adequate treatment when indicated.
The effect of thymoquinone on blood lipids in rats.
It is concluded that thymoquinone has a hypocholestrolemic as well as a reducing effect on triglycrides, HDL and LDL in albino rats.
Maximizing coronary disease risk reduction using nicotinic acid combined with LDL-lowering therapy
Correcting low HDL-cholesterol in statin-treated patients may provide a means to achieve the next leap forward in the management of cardiovascular disease.
Comparison of a Very Low-Carbohydrate and Low-Fat Diet on Fasting Lipids, LDL Subclasses, Insulin Resistance, and Postprandial Lipemic Responses in Overweight Women
Compared to a low-fat weight loss diet, a short-term very low-carbohydrate diet did not lower LDL-C but did prevent the decline in HDL-C and resulted in improved insulin sensitivity in overweight and obese, but otherwise healthy women.
Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: the role of nicotinic acid – a position paper developed by the European Consensus Panel on HDL-C*
SUMMARY Reduction of low-density lipoprotein cholesterol (LDL-C) is presently the primary focus of lipid-lowering therapy for prevention and treatment of coronary heart disease (CHD). However, the