Placebo-controlled study of divalproex sodium for agitation in dementia.

  title={Placebo-controlled study of divalproex sodium for agitation in dementia.},
  author={Anton P. Porsteinsson and Pierre N. Tariot and Rosemary Erb and Christopher Cox and Elaine M. Smith and Laura J Jakimovich and John A Noviasky and Nancy Kowalski and Connie J Holt and Carrie Irvine},
  journal={The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  volume={9 1},
The authors assessed the efficacy, tolerability, and safety of divalproex sodium for the treatment of agitation associated with dementia in a 6-week, randomized study of 56 nursing home patients with agitation and dementia treated with either placebo or individualized doses of divalproex sodium. Participants were blinded to treatment except for a physician-monitor and a pharmacist. When several covariates were taken into account, the drug/placebo difference in Brief Psychiatric Rating Scale… CONTINUE READING