Placebo, Prozac and PLoS: significant lessons for psychopharmacology

  title={Placebo, Prozac and PLoS: significant lessons for psychopharmacology},
  author={J. Horder and Paul R L Matthews and R. Waldmann},
  journal={Journal of Psychopharmacology},
  pages={1277 - 1288}
  • J. Horder, Paul R L Matthews, R. Waldmann
  • Published 2011
  • Medicine
  • Journal of Psychopharmacology
  • Kirsch et al. (2008, Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. PLoS Med 5: e45), conducted a meta-analysis of data from 35 placebo controlled trials of four newer antidepressants. They concluded that while these drugs are statistically significantly superior to placebo in acute depression, the benefits are unlikely to be clinically significant. This paper has attracted much attention and debate in both academic journals… CONTINUE READING

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    Placebo response in depression: a perspective for clinical practice.
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    Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration
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    The Emperor's New Drugs: An Analysis of Antidepressant Medication Data Submitted to the U.S. Food and Drug Administration
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