Place preference conditioning reveals the involvement of D1-dopamine receptors in the motivational properties of mu- and kappa-opioid agonists.

@article{Shippenberg1987PlacePC,
  title={Place preference conditioning reveals the involvement of D1-dopamine receptors in the motivational properties of mu- and kappa-opioid agonists.},
  author={T. S. Shippenberg and A. Herz},
  journal={Brain research},
  year={1987},
  volume={436 1},
  pages={169-72}
}
The role of D1 dopamine receptors in mediating the motivational properties of opioid agonists was investigated by use of place preference conditioning. Administration of the D1 receptor antagonist SCH 23390 (0.001-0.5 mg/kg) or the kappa-opioid receptor agonist U-69593 (0.16 mg/kg) produced conditioned place aversions. In contrast, the mu-opioid agonist, morphine (3.0 mg/kg) was appetitively reinforcing. Chronic infusion of SCH 23390 (1.0 mg/kg/day) during conditioning abolished the effects of… CONTINUE READING