Place navigation impaired in rats with hippocampal lesions

@article{Morris1982PlaceNI,
  title={Place navigation impaired in rats with hippocampal lesions},
  author={Richard G. M. Morris and Paul Garrud and J. Nicholas P. Rawlins and John O’Keefe},
  journal={Nature},
  year={1982},
  volume={297},
  pages={681-683}
}
Electrophysiological studies have shown that single cells in the hippocampus respond during spatial learning and exploration1–4, some firing only when animals enter specific and restricted areas of a familiar environment. Deficits in spatial learning and memory are found after lesions of the hippocampus and its extrinsic fibre connections5,6 following damage to the medial septal nucleus which successfully disrupts the hippocampal theta rhythm7, and in senescent rats which also show a correlated… 
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TLDR
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Medial septal lesions disrupt spatial mapping ability in rats.
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References

SHOWING 1-10 OF 14 REFERENCES
Loss of hippocampal theta rhythm results in spatial memory deficit in the rat.
TLDR
Although rats without theta rhythm could not find their way directly to the goal, they recognized its location when they came upon it by chance, indicating a type of spatial deficit similar to that shown by hippocampally lesioned patient H.M.
Hippocampus, space, and memory
TLDR
It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.
Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus
TLDR
A discrepancy between the clinical and animal literature could indicate a true evolutionary shift in the functions of the hippocampus, or, at the other extreme, it could simply reflect the use of incommensurate measures across species.
Place units in the hippocampus of the freely moving rat
Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.
  • C. Barnes
  • Biology, Psychology
    Journal of comparative and physiological psychology
  • 1979
TLDR
The amount of synaptic enhancement was statistically correlated with the ability to perform the circular platform task both within and between groups, and the aftereffects of the high-frequency stimulation selectively impaired the old rats' spontaneous alternation behavior on a T-maze.
Visual sampling after lesions of the superior colliculus in rats.
TLDR
In two separate experiments, rats with bilateral lesions of the superior colliculus showed significantly poorer relearning of a horizontal/vertical stripe discrimination than control animals, suggesting that when the stimulus and response sites are discontiguous, animals must make an appropriate orienting response in order to effectively sample the visual stimuli.
Spatial memory and hippocampal function
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