Place navigation impaired in rats with hippocampal lesions

  title={Place navigation impaired in rats with hippocampal lesions},
  author={Richard G. M. Morris and Paul Garrud and J. Nicholas P. Rawlins and John O’Keefe},
Electrophysiological studies have shown that single cells in the hippocampus respond during spatial learning and exploration1–4, some firing only when animals enter specific and restricted areas of a familiar environment. Deficits in spatial learning and memory are found after lesions of the hippocampus and its extrinsic fibre connections5,6 following damage to the medial septal nucleus which successfully disrupts the hippocampal theta rhythm7, and in senescent rats which also show a correlated… 
Effects of hippocampal lesions on patterned motor learning in the rat
Spatial conditional associative learning: effects of thalamo-hippocampal disconnection in rats
The findings support the idea that the anterior thalamic nuclei and the hippocampus are critical components of an anatomical system subserving spatial memory and suggest that these brain regions work in a dependent fashion during the performance of certain spatial learning tasks.
Conditional associative learning and the hippocampal system
The interaction between the hippocampus and subcortical structures via the fornix may be critical only for certain types of spatial learning and memory.
Hippocampal Lesions Impair Rapid Learning of a Continuous Spatial Alternation Task
The findings establish the W-track continuous alternation task as a hippocampally-dependent learning paradigm which may be useful for identifying changes in the neural representation of spatial sequences and reward contingencies as rats learn and apply new task rules.
Preserved configural learning and spatial learning impairment in rats with hippocampal damage
The results demonstrate that a spatial learning deficit in rats with hippocampal damage does not necessarily occur in the setting of a general configural learning impairment, as originally suggested by Sutherland and Rudy (1989).
Reversible Inactivation of the Hippocampal Mossy Fiber Synapses in Mice Impairs Spatial Learning, but neither Consolidation nor Memory Retrieval, in the Morris Navigation Task
The results suggest that mossy fibers are preferentially involved in new learning, consistent with the hypothesis that the hippocampal CA3 region might act as an autoassociation memory.
Hippocampal representation in place learning
The generality of the place-learning impairment associated with hippocampal system damage was challenged using methods of training that permitted subjects to form an individual association between
Medial septal lesions disrupt spatial mapping ability in rats.
It is suggested that damage to the septo-hippocampal cholinergic projection system produces a deficit in the formation or utilization of a spatial map (reference memory) that represents the location of a place with respect to the surrounding distal cues.


Loss of hippocampal theta rhythm results in spatial memory deficit in the rat.
Although rats without theta rhythm could not find their way directly to the goal, they recognized its location when they came upon it by chance, indicating a type of spatial deficit similar to that shown by hippocampally lesioned patient H.M.
Hippocampus, space, and memory
It is proposed that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.
Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus
A discrepancy between the clinical and animal literature could indicate a true evolutionary shift in the functions of the hippocampus, or, at the other extreme, it could simply reflect the use of incommensurate measures across species.
Place units in the hippocampus of the freely moving rat
Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.
  • C. Barnes
  • Biology, Psychology
    Journal of comparative and physiological psychology
  • 1979
The amount of synaptic enhancement was statistically correlated with the ability to perform the circular platform task both within and between groups, and the aftereffects of the high-frequency stimulation selectively impaired the old rats' spontaneous alternation behavior on a T-maze.
Visual sampling after lesions of the superior colliculus in rats.
In two separate experiments, rats with bilateral lesions of the superior colliculus showed significantly poorer relearning of a horizontal/vertical stripe discrimination than control animals, suggesting that when the stimulus and response sites are discontiguous, animals must make an appropriate orienting response in order to effectively sample the visual stimuli.
Spatial memory and hippocampal function