PlA polymorphism of integrin beta 3 differentially modulates cellular migration on extracellular matrix proteins.

@article{Sajid2002PlAPO,
  title={PlA polymorphism of integrin beta 3 differentially modulates cellular migration on extracellular matrix proteins.},
  author={Mansoor ud Din Sajid and Kamalakannan Vijayan and Shiloe Souza and PaulF. Bray},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2002},
  volume={22 12},
  pages={
          1984-9
        }
}
OBJECTIVE Cell migration is central to multiple physiological and pathologic processes and involves interactions between integrins on the cell surface and the extracellular matrix. The Leu33Pro (PlA) polymorphism of integrin beta3 has been reported to be associated with a greater rate of restenosis after angioplasty, a process involving endothelial and smooth muscle cell migration. We have addressed the possibility that the Leu33Pro polymorphism could modify the migratory behavior of Chinese… CONTINUE READING

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