Pkd2+/- vascular smooth muscles develop exaggerated vasocontraction in response to phenylephrine stimulation.

@article{Qian2007Pkd2VS,
  title={Pkd2+/- vascular smooth muscles develop exaggerated vasocontraction in response to phenylephrine stimulation.},
  author={Qi Qian and Larry W. Hunter and Hui Du and Qun Ren and Young Han and Gary C. Sieck},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 2},
  pages={485-93}
}
Vascular complications are the leading cause of morbidity and mortality in autosomal dominant polycystic kidney disease. Although evidence suggests an abnormal vascular reactivity, contractile function in Pkd mutant vessels has not been studied previously. Contractile response to phenylephrine (PE; 10(-10) to 10(-4)M), an alpha1-adrenergic receptor agonist, was examined. De-endothelialized Pkd2(+/-) aortic rings generated a higher maximum force (F(max)) than that in wild-type (wt; 5.78 +/- 0.73… CONTINUE READING