Pkb/Akt1 mediates Wnt/GSK3β/β-catenin signaling-induced apoptosis in human cord blood stem cells exposed to organophosphate pesticide monocrotophos.

@article{Kashyap2013PkbAkt1MW,
  title={Pkb/Akt1 mediates Wnt/GSK3β/β-catenin signaling-induced apoptosis in human cord blood stem cells exposed to organophosphate pesticide monocrotophos.},
  author={Mahendra Pratap Kashyap and Abhishek Kumar Singh and Vivek Kumar and Dharmendra Kumar Yadav and Feroz Khan and Sadaf Jahan and Vinay Kumar Khanna and Sanjay Yadav and Aditya Bhushan Pant},
  journal={Stem cells and development},
  year={2013},
  volume={22 2},
  pages={224-38}
}
Inhibition mechanisms of protein kinase B (Pkb)/Akt and its consequences on related cell signaling were investigated in human umbilical cord blood stem cells (hUCBSCs) exposed to monocrotophos (MCP, an organophosphate pesticide). In silico data reveal that MCP interacts with kinase and c-terminal regulatory domains of Akt1, resulting into a total docking score of 5.2748 and also forms H-bond between its N-H and Thr-291 residue of Akt1, in addition to possessing several hydrophobic interactions… CONTINUE READING