Pizotyline effectively attenuates the stimulus effects of N-Methyl-3,4-methylenedioxyamphetamine (MDMA)

@article{Young2005PizotylineEA,
  title={Pizotyline effectively attenuates the stimulus effects of N-Methyl-3,4-methylenedioxyamphetamine (MDMA)},
  author={Richard Young and Nantaka Khorana and Tatiana S Bondareva and Richard A Glennon},
  journal={Pharmacology Biochemistry and Behavior},
  year={2005},
  volume={82},
  pages={404-410}
}

Generalization of serotonin and dopamine ligands to the discriminative stimulus effects of different doses of ±3,4-methylenedioxymethamphetamine

The results suggest some differences in the role of serotonin and dopamine in the discriminative stimulus effects of a low versus a higher dose of MDMA.

Dopamine and serotonin antagonists fail to alter the discriminative stimulus properties of ±methylenedioxymethamphetamine

The results suggest that either one of the serotonergic and 5HTergic mechanisms is sufficient, but not required, to maintain the stimulus effects of MDMA.

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Cyproheptadine resembles clozapine in vivo following both acute and chronic administration in rats

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Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease.

Treatment with pizotifen activated ERK in the striatum, reduced neurodegeneration and significantly enhanced motor performance in the R6/2 HD mouse model, suggesting that pizotin and related approved drugs may provide a basis for developing disease modifying therapeutic interventions for HD.

A Validated RP-HPLC Method for the Estimation of Pizotifen in Pharmaceutical Dosage Form

A simple, selective, linear, precise, and accurate RP-HPLC method was developed and validated for rapid assay of Pizotifen in pharmaceutical dosage form. Isocratic elution at a flow rate of 1.0

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