Pizotyline effectively attenuates the stimulus effects of N-Methyl-3,4-methylenedioxyamphetamine (MDMA)

  title={Pizotyline effectively attenuates the stimulus effects of N-Methyl-3,4-methylenedioxyamphetamine (MDMA)},
  author={Richard Young and Nantaka Khorana and Tatiana S Bondareva and Richard A Glennon},
  journal={Pharmacology Biochemistry and Behavior},

Generalization of serotonin and dopamine ligands to the discriminative stimulus effects of different doses of ±3,4-methylenedioxymethamphetamine

The results suggest some differences in the role of serotonin and dopamine in the discriminative stimulus effects of a low versus a higher dose of MDMA.

Dopamine and serotonin antagonists fail to alter the discriminative stimulus properties of ±methylenedioxymethamphetamine

The results suggest that either one of the serotonergic and 5HTergic mechanisms is sufficient, but not required, to maintain the stimulus effects of MDMA.

Serotonin and serotonin receptors in hallucinogen action

Psilocybin-induced stimulus control in the rat

TDIQ (5,6,7,8-tetrahydro-1,3-dioxolo [4,5-g]isoquinoline): discovery, pharmacological effects, and therapeutic potential.

  • R. Young
  • Biology, Psychology
    CNS drug reviews
  • 2007
TDIQ could be a forerunner for a new type of chemical entity in the treatment of certain forms of anxiety and/or obesity and serve as a structural template in the discovery and development of additional agents that might be selective for alpha(2)-adrenergic receptors.

Cyproheptadine resembles clozapine in vivo following both acute and chronic administration in rats

It is demonstrated that in vivo cyproheptadine resembles clozapine both acutely and chronically, suggesting that further study of cypro heptane in conjunction with a ‘typical’ APD for the possible treatment of schizophrenia is merited at both pre-clinical and clinical levels.

Cyproheptadine prevents pergolide-induced valvulopathy in rats: an echocardiographic and histopathological study.

Cyproheptadine prevented pergolide-induced valvulopathy in rats, which was associated with a reduced number of 5-HT(2B)R-positive valvular cells, which may have important clinical implications for the prevention of serotonergic drug-inducedValvular heart disease.

Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease.

Treatment with pizotifen activated ERK in the striatum, reduced neurodegeneration and significantly enhanced motor performance in the R6/2 HD mouse model, suggesting that pizotin and related approved drugs may provide a basis for developing disease modifying therapeutic interventions for HD.

A Validated RP-HPLC Method for the Estimation of Pizotifen in Pharmaceutical Dosage Form

A simple, selective, linear, precise, and accurate RP-HPLC method was developed and validated for rapid assay of Pizotifen in pharmaceutical dosage form. Isocratic elution at a flow rate of 1.0



Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)

  • M. D. Schechter
  • Psychology, Biology
    Pharmacology Biochemistry and Behavior
  • 1988

MDMA Stimulus Generalization to the 5-HT1A Serotonin Agonist 8-Hydroxy-2- (di-n-propylamino)tetralin

Behavioral effects of 5-methoxy-N,N-dimethyltryptamine and dose-dependent antagonism by BC-105

The discriminative effects of 5-methoxy-N,N-dimethyltryptamine (5-OMeDMT) were studied in rats trained to discriminate 1.5mg/kg or 3.0 mg/kg from saline and found that antagonism of the 5-OMEDMT stimulus response by the presumed serotonin antagonist BC-105 depended on the dose of 5/O-MeDMT.

Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies

The results indicate that the overall psychological effects of MDMA largely depend on carrier‐mediated 5‐HT release, while the more stimulant‐like euphoric mood effects of ecstasy appear to relate, at least in part, to dopamine D2 receptor stimulation.

3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.

It is found that long-term MDMA use could lead to the development of fenfluramine-like VHD, and the necessity of screening current and future drugs at h5-HT2B receptors for agonist actions before their use in humans is underscored.

Differentiation between the stimulus effects of l-5-hydroxytryptophan and LSD.