Pixantrone (BBR2778) reduces the severity of experimental allergic encephalomyelitis

@article{Cavaletti2004PixantroneR,
  title={Pixantrone (BBR2778) reduces the severity of experimental allergic encephalomyelitis},
  author={Guido Cavaletti and Ennio Cavalletti and Luca Crippa and Eric di Luccio and Francesco Lolli},
  journal={Journal of Neuroimmunology},
  year={2004},
  volume={151},
  pages={55-65}
}
Pixantrone is less cardiotoxic and is similarly effective to mitoxantrone (MTX) as an antineoplastic drug. In our study, pixantrone reduced the severity of acute and decreased the relapse rate of chronic relapsing experimental allergic encephalomyelitis (EAE) in rats. A marked and long-lasting decrease in CD3+, CD4+, CD8+ and CD45RA+ blood cells and reduced anti-MBP titers were observed with both pixantrone and MTX. In vitro mitogen- and antigen-induced T-cell proliferation tests of human and… CONTINUE READING
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