Piwi proteins and piRNAs in mammalian oocytes and early embryos: From sample to sequence

@inproceedings{Rosenkranz2015PiwiPA,
  title={Piwi proteins and piRNAs in mammalian oocytes and early embryos: From sample to sequence},
  author={David Rosenkranz and Chung-Ting Han and Elke F. Roovers and Hans Zischler and Ren{\'e} F Ketting},
  booktitle={Cell reports},
  year={2015}
}
Germ cells of most animals critically depend on piRNAs and Piwi proteins. Surprisingly, piRNAs in mouse oocytes are relatively rare and dispensable. We present compelling evidence for strong Piwi and piRNA expression in oocytes of other mammals. Human fetal oocytes express PIWIL2 and transposon-enriched piRNAs. Oocytes in adult human ovary express PIWIL1 and PIWIL2, whereas those in bovine ovary only express PIWIL1. In human, macaque, and bovine ovaries, we find piRNAs that resemble testis… CONTINUE READING
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Piwi proteins and piRNAs in mammalian oocytes and early embryos

  • D. Rosenkranz, M. Mahdipour, +8 authors R. F. Ketting
  • Cell Rep .
  • 2015

Grif fi thsJones , The microRNA Registry

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