Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas

  title={Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas},
  author={Jonas Felix Busch and Bernhard Ralla and Monika Jung and Zofia Wotschofsky and Elena Trujillo-Arribas and Philipp Schwabe and Ergin Kilic and A Giroir Fendler and Klaus Jung},
  booktitle={Journal of experimental & clinical cancer research : CR},
BACKGROUND Piwi-interacting RNAs (piRNAs) are small RNAs of 27-30 nucleotides mapping to transposons or clustering in repeat genomic regions. Preliminary studies suggest an important role in cancerogenesis. This study is the first one investigating their prognostic impact in clear cell renal cell cancer (ccRCC) patients. METHODS Three piRNAs (piR-30924, piR-57125, and piR-38756) selected on the basis of initial piRNA microarray analyses were determined using RT-qPCR in non-metastatic (n = 76… CONTINUE READING
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