Piwi-Interacting RNAs (piRNAs) Are Dysregulated in Renal Cell Carcinoma and Associated with Tumor Metastasis and Cancer-Specific Survival

@article{Li2015PiwiInteractingR,
  title={Piwi-Interacting RNAs (piRNAs) Are Dysregulated in Renal Cell Carcinoma and Associated with Tumor Metastasis and Cancer-Specific Survival},
  author={Yuping Li and Xiwei Wu and Hanlin Gao and Jennifer M. Jin and Arthur Xuejun Li and Young Sik Kim and Sumanta Kumar Pal and Rebecca A Nelson and Clayton M Lau and Chao Guo and Bing Song Mu and Jinhui Wang and Frances M. Wang and Jessica S Wang and Yuanyin Zhao and Wengang Chen and John J. Rossi and Lawrence M. Weiss and Huiqing Wu},
  journal={Molecular Medicine},
  year={2015},
  volume={21},
  pages={381-388}
}
Piwi-interacting RNAs (piRNAs) are a distinct group of small noncoding RNAs (sncRNAs) that silence transposable genetic elements to protect genome integrity. Because of their limited expression in gonads and sequence diversity, piRNAs remain the most mysterious class of small RNAs. Studies have shown piRNAs are present in somatic cells and dysregulated in gastric, breast and liver cancers. By deep sequencing 24 frozen benign kidney and clear cell renal cell carcinoma (ccRCC) specimens and using… CONTINUE READING
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Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Piwi-interacting RNAs in cancer: emerging functions and clinical utility

  • Molecular Cancer
  • 2016
VIEW 8 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Small non‐coding RNA and colorectal cancer

  • Journal of cellular and molecular medicine
  • 2019

PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer.

  • Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
  • 2017

References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

PIWI-interacting small RNAs: the vanguard of genome defence

  • Nature Reviews Molecular Cell Biology
  • 2011
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Novel dimensions of piRNAs in cancer.

  • Cancer letters
  • 2013
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

MicroRNA profiling of clear cell renal cell carcinoma by whole-genome small RNA deep sequencing of paired frozen and formalin-fixed, paraffin-embedded tissue specimens

L Weng
  • J. Pathol
  • 2010
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Altered expression of piRNAs and their relation with clinicopathologic features of breast cancer

G Huang
  • Clin. Transl. Oncol
  • 2013
VIEW 1 EXCERPT

Altered expression of piRNAs and their relation with clinicopathologic features of breast cancer . Clin . Transl . Oncol

Y Mei, D Clark, L Mao
  • 2013

Identification of a 4 - microRNA signature for clear cell renal cell carcinoma metastasis and prognosis . PLoS One

KC Pang
  • 2012

Identification of a 4-microRNA signature for clear cell renal cell carcinoma metastasis and prognosis

X Wu
  • PLoS One. 7:e35661
  • 2012
VIEW 2 EXCERPTS

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