Pivoting of microtubules driven by minus end directed motors leads to their alignment to form an interpolar bundle

@inproceedings{Winters2018PivotingOM,
  title={Pivoting of microtubules driven by minus end directed motors leads to their alignment to form an interpolar bundle},
  author={Lora Winters and Ivana Ban and Marcel Prelogovi{\'c} and Nenad Pavin and Iva M Toli{\'c}},
  year={2018}
}
At the beginning of mitosis, the cell forms a spindle made of microtubules and associated proteins to segregate chromosomes. An important part of spindle architecture is a set of antiparallel microtubule bundles connecting the two spindle poles. A key question is how microtubules extending at arbitrary angles form an antiparallel interpolar bundle. Here we show that microtubules meet at an oblique angle and subsequently rotate into antiparallel alignment. By combining experiments with theory… CONTINUE READING

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