Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity.

@article{Guinan1994PivotalRO,
  title={Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity.},
  author={Eva C. Guinan and John G Gribben and Vassiliki A Boussiotis and Gordon J Freeman and Lee M. Nadler},
  journal={Blood},
  year={1994},
  volume={84 10},
  pages={
          3261-82
        }
}
The above story illustrates the translation of basic scientific discoveries to the clinic. In vitro and preclinical in vivo experimentation suggests that modulation of the B7:CD28 pathway will result in either amplification or suppression of the immune response. Considering the frequency with which diseases characterized by either inadequate or dysregulated immune function present to the practicing hematologist or oncologist, it is not difficult to envisage clinical applications for reagents… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 108 CITATIONS, ESTIMATED 80% COVERAGE

Impairment of T-cell activation in head and neck cancer in situ and in vitro: strategies for an immune restoration.

  • Archives of otolaryngology--head & neck surgery
  • 1999
VIEW 6 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Costimulatory molecules in ocular cicatricial pemphigoid.

  • Investigative ophthalmology & visual science
  • 1998
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Mesenchymal stem cells avoid allogeneic rejection

VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Osteoarthritic articular chondrocytes stimulate autologous T cell responses in vitro.

  • Clinical and experimental rheumatology
  • 2003
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Microbial lectins and their prospective mitogenic potential.

  • Critical reviews in microbiology
  • 2014
VIEW 1 EXCERPT
CITES BACKGROUND

Construction, and in vitro and in vivo analyses of tetravalent immunoadhesins.

  • Journal of microbiology and biotechnology
  • 2012
VIEW 1 EXCERPT
CITES RESULTS

FILTER CITATIONS BY YEAR

1995
2018

CITATION STATISTICS

  • 4 Highly Influenced Citations