Pivotal role of plasminogen-activator inhibitor 1 in vascular disease.

@article{Agirbasli2005PivotalRO,
  title={Pivotal role of plasminogen-activator inhibitor 1 in vascular disease.},
  author={Mehmet Ali Agirbasli},
  journal={International journal of clinical practice},
  year={2005},
  volume={59 1},
  pages={
          102-6
        }
}
Fibrinolysis plays a crucial role in the development of vascular disease. The interface between the plasminogen activators and inhibitors determines the fibrinolytic potential of human blood. In addition to fibrin degradation, fibrinolytic system components modulate several complex biological events such as angiogenesis, tumorigenesis, arteriosclerosis and cellular migration. Recent experimental and clinical data indicated that PAI-1 as a novel vascular risk factor. In this concise review, we… CONTINUE READING
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