Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression

@article{Miyao2015PivotalRO,
  title={Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression},
  author={Masashi Miyao and Hirokazu Kotani and Tokiko Ishida and Chihiro Kawai and Sho Manabe and Hitoshi Abiru and Keiji Tamaki},
  journal={Laboratory Investigation},
  year={2015},
  volume={95},
  pages={1130-1144}
}
Liver sinusoidal endothelial cells (LSECs) are involved in the transport of nutrients, lipids, and lipoproteins, and LSEC injury occurs in various liver diseases including nonalcoholic fatty liver disease (NAFLD). However, the association between LSEC injury and NAFLD progression remains elusive. Accordingly, in this study, we aimed to elucidate the precise role of LSEC in the pathophysiology of NAFLD using two different mouse models, namely the choline-deficient, L-amino acid-defined and high… CONTINUE READING