Pivotal role of interleukin-8 in the acute respiratory distress syndrome and cerebral reperfusion injury.

@article{Matsumoto1997PivotalRO,
  title={Pivotal role of interleukin-8 in the acute respiratory distress syndrome and cerebral reperfusion injury.},
  author={Tadashi Matsumoto and Kenji Yokoi and Naofumi Mukaida and Akihisa Harada and Junji Yamashita and Yoshihisa Watanabe and Kouji Matsushima},
  journal={Journal of leukocyte biology},
  year={1997},
  volume={62 5},
  pages={581-7}
}
Neutrophil recruitment is one of the hallmarks of acute inflammation. A potent neutrophil chemotactic and activating factor, interleukin-8 (IL-8), has been demonstrated to be elevated in body fluids in various human diseases and experimental animal models. Recent investigations on animal disease models using blocking antibodies to IL-8 have revealed the essential involvement of IL-8 in acute inflammation. We previously reported that the administration of a neutralizing antibody against IL-8… CONTINUE READING

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