Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication.

@article{Secchiero2000PivotalRO,
  title={Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication.},
  author={Paola Secchiero and Davide Zella and Sabrina Curreli and Prisco Mirandola and Silvano Capitani and Robert C. Gallo and Giorgio Zauli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 26},
  pages={14620-5}
}
We show here that HIV type 1 (HIV-1) Tat protein, in combination with anti-CD3/CD28 mAbs, promotes IL-2 production and proliferation of primary CD4(+) T lymphocytes, obtained from HIV-1-seronegative donors. This effect was observed when Tat was immobilized on a solid support, but it was not observed with soluble Tat. Such hyperactivation was accomplished by recruiting the rolipram-sensitive cyclic nucleoside phosphodiesterase 4 and resulted in increased susceptibility to HIV-1 infection… CONTINUE READING

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