Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice.

@article{Yoneyama1998PivotalRO,
  title={Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice.},
  author={Hiroshi Yoneyama and Akihisa Harada and Toshio Imai and Mitsuo Baba and Osamu Yoshie and Yuzhi Zhang and Hideyoshi Higashi and Masako Murai and Hitoshi Asakura and Kouji Matsushima},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={102 11},
  pages={1933-41}
}
Thymus and activation-regulated chemokine (TARC) is a recently identified lymphocyte-directed CC chemokine which specifically chemoattracts T helper type 2 CD4(+) T cells in human. To establish the pathophysiological roles of TARC in vivo, we investigated whether a monoclonal antibody (mAb) against TARC could inhibit the induction of hepatic lesions in murine model using Propionibacterium acnes and lipopolysaccharide (LPS). P. acnes-induced intrahepatic granuloma formation in the priming phase… CONTINUE READING