Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction.

  title={Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction.},
  author={Thomas Tapmeier and A d'Arcy Fearn and Kathryn A. Brown and Paramit Chowdhury and Steven H Sacks and Neil S Sheerin and Wilson Wai-Ho Wong},
  journal={Kidney international},
  volume={78 4},
Tubulointerstitial fibrosis is a common consequence of a diverse range of kidney diseases that lead to end-stage renal failure. The degree of fibrosis is related to leukocyte infiltration. Here, we determined the role of different T cell populations on renal fibrosis in the well-characterized mouse model of unilateral ureteric obstruction. Depletion of CD4(+) T cells in wild-type mice with a monoclonal antibody significantly reduced the amount of interstitial expansion and collagen deposition… CONTINUE READING
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