Pivotal advance: The promotion of soluble DC-SIGN release by inflammatory signals and its enhancement of cytomegalovirus-mediated cis-infection of myeloid dendritic cells.

@article{Plazolles2011PivotalAT,
  title={Pivotal advance: The promotion of soluble DC-SIGN release by inflammatory signals and its enhancement of cytomegalovirus-mediated cis-infection of myeloid dendritic cells.},
  author={Nicolas Plazolles and J-M Humbert and Laurence Vachot and Bernard Verrier and Carsten Hocke and Frank Halary},
  journal={Journal of leukocyte biology},
  year={2011},
  volume={89 3},
  pages={329-42}
}
DC-SIGN is a member of the C-type lectin family. Mainly expressed by myeloid DCs, it is involved in the capture and internalization of pathogens, including human CMV. Several transcripts have been identified, some of which code for putative soluble proteins. However, little is known about the regulation and the functional properties of such putative sDC-SIGN variants. To better understand how sDC-SIGN could be involved in CMV infection, we set out to characterize biochemical and functional… CONTINUE READING
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