Pivotal Role for Monocytes/Macrophages and Dendritic Cells in Maternal Immune Response to the Developing Embryo in Cattle1

@inproceedings{MansouriAttia2012PivotalRF,
  title={Pivotal Role for Monocytes/Macrophages and Dendritic Cells in Maternal Immune Response to the Developing Embryo in Cattle1},
  author={N. Mansouri-Attia and Lilian J Oliveira and N. Forde and A. Fahey and J. Browne and J. Roche and O. Sandra and P. Reinaud and P. Lonergan and T. Fair},
  booktitle={Biology of reproduction},
  year={2012}
}
ABSTRACT In mammals, successful pregnancy is dependent in part on the adaptation or regulation of the maternal immune system to prevent the rejection of the embryonic semiallograft. A modification in Th cell function and secretion is a requirement for the establishment and maintenance of pregnancy. Although there is strong evidence from studies in humans and mice linking successful pregnancy with the predominance of Th2-type immunity, the situation in cattle remains unclear. This study… Expand
The Contribution of the Maternal Immune System to the Establishment of Pregnancy in Cattle
  • T. Fair
  • Biology, Medicine
  • Front. Immunol.
  • 2015
TLDR
Key contributions of immune cell populations include granulocyte involvement in follicle differentiation and gamete transfer, monocyte invasion of the peri-ovulatory follicle and their subsequent role in corpus luteum formation and the pivotal roles of maternal macrophage and dendritic cells in key steps of the establishment of pregnancy, particularly, the maternal immune response to the embryo. Expand
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TLDR
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TLDR
The endometrial immune profile of the oestrous cycle favours a Th2 environment in anticipation of pregnancy and the presence of an embryo acts to fine tune this environment. Expand
Bovine embryo induces an anti-inflammatory response in uterine epithelial cells and immune cells in vitro: possible involvement of interferon tau as an intermediator
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The findings suggest that the bovine embryo, in the first four days in the uterus (D5-D9), starts to induce an anti-inflammatory response in epithelial cells and in immune cells. Expand
Symposium review: Immunological detection of the bovine conceptus during early pregnancy.
  • T. Ott
  • Medicine, Biology
  • Journal of dairy science
  • 2019
TLDR
Current results support the hypothesis that early pregnancy signaling in dairy heifers involves changes in the proportions of immune cells in the endometrium as well as induction of molecules known to mediate tolerance, likely essential for uterine wall remodeling, placentation, and successful pregnancy. Expand
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TLDR
The hypothesis that myeloid lineage cells with a tolerogenic phenotype are involved in establishment of pregnancy in dairy heifers is supported. Expand
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TLDR
The main components of the innate immune response that are involved with early pregnancy and their importance to avoid conceptus rejection are focused on. Expand
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TLDR
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Maternal immune responses to conceptus signals during early pregnancy in ruminants
TLDR
Evidence is mounting that conceptus signals induce a tolerogenic bias in immune cell function at the fetal-maternal interface, accompanied by tissue remodeling and angiogenesis facilitated by tissue-resident immune cells that sets the trajectory for placental growth and, ultimately, fetal growth. Expand
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