Pivagabine effects on neuroendocrine responses to experimentally-induced psychological stress in humans

@article{Gerra2001PivagabineEO,
  title={Pivagabine effects on neuroendocrine responses to experimentally-induced psychological stress in humans},
  author={G. Gerra and A. Zaimovic and F. Giusti and M. C. Baroni and F. Brambilla},
  journal={Behavioural Brain Research},
  year={2001},
  volume={122},
  pages={93-101}
}
Neuroendocrinology of chronic stress seems to be characterized by HPA axis hyperactivity and early childhood stressors have been hypothesized to predispose individuals to adult onset depression by means of dysregulation of the HPA axis. Pivagabine (PVG), a hydrophobic 4-aminobutyric acid derivative, has been used experimentally recently in the treatment of different disorders related to stress-maladaptation, because of its possible inhibitory action on corticotrophin releasing factor secretion… Expand
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