Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.

@article{Wang2014Pitx2microRNAPT,
  title={Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.},
  author={Jun Wang and Yan Bai and Na Li and Wenduo Ye and Min Zhang and Stephanie B. Greene and Ye Tao and YiPing Chen and Xander H T Wehrens and James F. Martin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 25},
  pages={9181-6}
}
The molecular mechanisms underlying atrial fibrillation, the most common sustained cardiac arrhythmia, remain poorly understood. Genome-wide association studies uncovered a major atrial fibrillation susceptibility locus on human chromosome 4q25 in close proximity to the paired-like homeodomain transcription factor 2 (Pitx2) homeobox gene. Pitx2, a target of the left-sided Nodal signaling pathway that initiates early in development, represses the sinoatrial node program and pacemaker activity on… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 49 references

Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2013

Sinus node dysfunction and atrial fibrillation: two sides of the same coin?

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology • 2013

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