Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.

  title={Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.},
  author={Jun Wang and Yan Bai and Na Li and Wenduo Ye and Min Zhang and Stephanie B. Greene and Ye Tao and YiPing Chen and Xander H T Wehrens and James F. Martin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 25},
The molecular mechanisms underlying atrial fibrillation, the most common sustained cardiac arrhythmia, remain poorly understood. Genome-wide association studies uncovered a major atrial fibrillation susceptibility locus on human chromosome 4q25 in close proximity to the paired-like homeodomain transcription factor 2 (Pitx2) homeobox gene. Pitx2, a target of the left-sided Nodal signaling pathway that initiates early in development, represses the sinoatrial node program and pacemaker activity on… CONTINUE READING
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